Consanguineous Marriage & its Impact on Genetic Eye Disorder

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Consanguineous Marriage & its Impact on Genetic Eye Disorder

Consanguineous marriage or marriage between close relatives can also increase the risk of genetic disorder which will affect vision in some cases. Non dominant genetic condition like color blindness, congenital cataract and retinitis pigmentosa can pass to next generation if parents have that gene, some genetic condition are autosomal non dominant which means both parent should have 1 faulty gene to inherit in child. In consanguinity there are high chances that both parent contains 1 faulty gene which says only 25% chance on passing to offspring. In autosomal dominant only 1 gene from single parent is enough to cause the condition which means 50%chances of inheritance. X linked inheritance are disorder which are related x chromosome to show impact on inheritent.

In eye condition much genetic condition passes through autosomal non dominant inheritance like Retinitis Pigmentosa which can be because of consanguinity. It is a condition which leads to vision loss and can lead to blindness. Another condition can be Congenital Cataract which can lead to vision impairment and should be treated earliest. Albinism another condition which can lead to vision problem and is inherited through autosomal non dominant pattern.

How to manage the risk: Genetic counseling is important which can help people to understand the risk in consanguineous marriage, parental genetic testing can help people to understand before family planning.

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